Control of the chemical cross-linking of gelatin by a thermosensitive polymer: example of switchable reactivity.
نویسندگان
چکیده
Chemical cross-linking of gelatin is achieved using a thermosensitive reactive copolymer based on N-isopropylacrylamide (NIPAM). The copolymer bears 5 mol % acrylic acid units which form amide bonds with the amino groups of gelatin in the presence of a water-soluble carbodiimide. The cross-linking reaction occurs only below the LCST congruent with 34 degrees C (lower critical solution temperature), i.e., when the copolymer is in the coil conformation. Above the LCST the copolymer adopts a globule conformation and its ability to react with gelatin is drastically reduced. By setting the temperature above or below the LCST it is possible to switch off or on the reactivity of the system and control the gelation process. The switch temperature can be set at the desired value by adjusting the composition of the thermosensitive copolymer.
منابع مشابه
Inverse Miniemulsion Method for Synthesis of Gelatin Nanoparticles in Presence of CDI/NHS as a Non-toxic Cross-linking System
In this research, gelatin nanoparticles were synthesized via inverse miniemulsion method by employing a mixture of a water soluble carbodiimide (CDI) and N-hydroxysuccinimide (NHS) as a non-toxic cross-linking system. The gelatin nanoparticles were characterized for their size and size distribution, morphology and stability and were compared with those of nanoparticles cross-linked by glutarald...
متن کاملChemical cross linking versus high energy electron beam cross linking of HDPE: electrical properties study
Cross linking of high density polyethylene (HDPE) was first performed via high energy10 Mev electron beam (EB) irradiation. HDPE was also cross linked withDicumyle peroxide (DCP).The gel content of samples was determined by solvent extraction.Degree of cross linking was evaluated by hot set apparatus; as well .In order to clarify the effectof nature of cross linking, correlation of electrical p...
متن کاملEffect of Some Synthetic Parameters on Size and Polydispersity Index of Gelatin Nanoparticles Cross-Linked by CDI/NHS System
In our previous work, the effect of use of a water soluble CDI/NHS system as nontoxic cross-linking agent on fabrication of gelatin nanoparticles was investigated. In this research, the effect of variation in some synthetic parameters of gelatin nanoparticles cross-linked by CDI/NHS system such as type of gelatin and formulation of cross- linking agent on their size and distribution was examine...
متن کاملThe Effect of Structural Parameters on the Cross-Linking of Various Grades of LLDPE
Polyethylene’s application for insulating is highly advanced but due to thermoplastic properties, its application confronts constraints such as the limited 70°C temperature of the conductor. Polyethylene thermosetting procedure in which molecules are knotted and a 3D-molecular-network formed is developed to conquer the mentioned problem and to raise the applicable temperature of the i...
متن کاملOptimization of morphology and geometry of encapsulated Hypophthalmichthys molitrix oil
In the present study, the effect of stirring speed and the type of cross linking agent on the size and formation of microencapsulated Silver carp (Hypophthalmichthys molitrix) oil were investigated. The gelatin/gum Arabic was used for encapsulating and the capsules were prepared by complex coacervation. Microcapsules were analyzed by optical microscopy technique and particle size analyzer. Re...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Biomacromolecules
دوره 6 6 شماره
صفحات -
تاریخ انتشار 2005